Manuela Orjuela, MD, ScM, focuses her research on gene-nutrient and gene-environment interactions during pregnancy and early childhood and the development of early carcinogentic changes in childhood cancer, with a principal focus on retinoblastoma. She has led a multidisciplinary team examining gene-nutrient and epigenetic risk factors for retinoblastoma in collaboration with investigators in the U.S., Mexico, and Canada, including the Hospital Infantil de Mexico, the Hospital de Pediatria of the IMSS, the Instituto Nacional de Salud Publica, the Instituto de Fisiologia Celular of the UNAM, the USDA laboratory on Aging at Tufts University, Mount Sinai Medical Center, and the University of Toronto. As a member of the Columbia Center for Children’s Environmental Health, Dr. Orjuela has led a collaboration with the Center, the laboratory of Cytogenetics at Columbia, and the Leukemia Research Laboratory of the UK Institute for Cancer Research, examining development of chromosomal aberrations and specific pre-leukemic genetic changes in the Center. Dr. Orjuela is the academic track director for the Global Health Track in Environmental Health Sciences at the Mailman School and has a joint appointment in the Division of Pediatric Oncology at Columbia College of Physicians & Surgeons.
Affiliations:
Columbia Center for Environmental Health in Northern Manhattan
Division of Pediatric Oncology
Herbert Irving Cancer Center
Member, Children's Oncology Group
Member, Herbert Irving Comprehensive Cancer Center, Molecular Epidemiology Committee
Member, NCI Brain Tumor Epidemiology Consortium (BTEC)
Honors & Awards:
1998 Dr. Alexandro Aguirre Prize, Sociedad Latinoamericana de Oncologia Pediatrica
2002 American Association for Cancer Research Minority Scholar: Cancer Prevention
Invited Lecturer First International Symposium on Retinoblastoma, Campinas Brazil, March 2003
Selected Publications:
GL Chantada , F Doz , M Orjuela ,I Qaddoumi, RS Sitorus, TKepak, AFurmanchuk, MCastellanos, Tsharma, P Chevez-Barrios, C Rodriguez-Galindo "World disparities in risk definition and management of Retinoblastoma." A report from the International Retinoblastoma Staging Working Group. Pediatr Blood Cancer. 50 692-4 2008
Bocskay KA, Orjuela MA, Tang D, Liu X, Warburton D, Perera FP. "Fluorescence in situ hybridization is necessary to detect an association between chromosome aberrations and polycyclic aromatic hydrocarbon exposure in utero and reveals nonrandom chromosome involvement." Environ Mol Mutagen. 48 114-23 2007
Rundle, A., Madsen, A., Orjuela, M., Mooney, L., Tang, D., Kim, M., Perera, F. "The association between Benzo[a]pyrene-DNA adducts and body mass index, calorie intake and physical activity." J Urban Health 84 722-32 2007
Rundle, A., Orjuela, M., Tang, D., Kim, M., Richie, J., L.A. Mooney, Perera, F. "Preliminary studies on the effect of moderate physical activity on blood levels of glutathione" Biomarkers 10 390-400 2005
M. A. Orjuela, L. Titievsky, X. Liu, M. Ramirez-Ortiz, M. V. Ponce-Castaneda, E. Lecona, E. Molina, K. Beaverson, D. H. Abramson, and Nancy Mueller. "Fruit and vegetable intake during pregnancy and risk for development of sporadic retinoblastoma" Cancer Epidemiology Biomarkers and Prevention 14 1433-40 2005
Bocskay, K., Orjuela, M., Tang, D., Warburton D, Perera, F. "Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons" Cancer Epidemiology Biomarkers and Prevention 14 506-11 2005
L.A. Mooney, A Madsen, D. Tang, M.A. Orjuela, WY Tsai, ER Garduno, FP Perera, "Antioxidant Vitamin Supplementation Reduces Benzo(a)pyrene-DNA Adducts and Potential Cancer Risk in Female Smokers" Cancer Epidemiol Biomarkers Prev 14 237-242 2005
Orjuela, M., Gross, T.G., Cheung, Y.K., Alobeid, B., Morris, E., Cairo, M.S. A "A Pilot Study of Chemoimmunotherapy (Cyclophosphamide, Prednisone, and Rituximab)(CPR) in patients with Post-Transplant Lymphoproliferative Disorder (PTLD) following Solid Organ Transplant (SOT)" Clinical Cancer Research 9 3945-3952 2003
Orjuela M., Orlow I., Dudas M., Ponce-Castañeda V., Salazar A., Leal C., Ridaura C., Abramson D., Gerald W., and Cordon-Cardo C. "Alterations of Cell Cycle regulators affecting the RB-pathway in non-familial retinoblastoma" Human Pathology 32 537-544 2001
Orjuela M, Ponce V, Ridaura C, Lecona, E., Leal, C., Abramson, D., Orlow, I., Gerald W, Cordon-Cardo C "Presence of Human Papilloma Virus in tumor tissue from children with retinoblastoma: an alternative mechanism for tumor development." Clinical Cancer Research 6 4010-6 2000
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