Matthew Perzanowski, PhD

Dr. Matthew Perzanowski’s research is focused on understanding exposures that lead to allergic sensitization and asthma. While many environmental exposures are hypothesized to have contributed to the global asthma epidemic that started in the latter half of the 20th century, a unifying theory has not been proven. Dr. Perzanowski began his research career at a preeminent allergen exposure laboratory and participated in studies conducted in communities as different as inner-city Atlanta and rural Kenya. He continued with his doctoral research working with the OLIN group in northern Sweden at the Arctic Circle where asthma is common but dust mites and cockroaches, exposure to which is important to asthma elsewhere, are not found. As a co-investigator on several established prospective cohort studies, Dr. Perzanowski’s current research is exploring paradigms of exposures related to asthma in an area of the world with one of the greatest asthma burdens, low and middle-income neighborhoods in New York City. He is the principal investigator on the NIH (NIEHS) and HUD funded, NYC Neighborhood Asthma and Allergy Study which is examining neighborhood differences in asthma prevalence and persistence to better understand the disparity in asthma risk between children living just city blocks apart. Two other major research aims of his laboratory work are implementing non-invasive measurements of airway inflammation in pediatric population based studies and evaluating the relevance of the ‘hygiene hypothesis’ to inner-city asthma.

Dr. Perzanowski served as one of the primary investigators on the Center’s DISCOVER Initiative.

Affiliations:

Columbia Center for Environmental Health in Northern Manhattan

Member, New York City Asthma Partnership

Member, American Academy of Allergy, Asthma and Immunology

Selected Publications:
Perzanowski MS, Chew, GL, Divjan A, Jung KH, Ridder R, Tang D, Diaz D, Goldstein IF, Kinney PL, Rundle AG, Camann D, Perera FP, Miller RL (2012). Early-life exposure to cockroach allergen and airborne polycyclic aromatic hydrocarbons predict development of sensitization to cockroach among inner-city children. Submitted.

Perzanowski MS, Miller RL, Tang D, Ali DB, Garfinkel RS, Chew GL, Goldstein IF, Perera FP, Barr RG "Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban, low-income cohort." Thorax in press

Perzanowski MS, Platts-Mills, TAE "Further confirmation of the relevance of cockroach and dust mite sensitization to inner-city asthma morbidity" Clin Exp Allergy 39 1291-3 2009

Perzanowski MS, Chew GL, Divjan A, Johnson A, Panjwani K, Sheares BJ, Goldstein IF, Garfinkel RS, Platts-Mills TA, Perera FP, Miller RL "Cat ownership is a risk factor for developing anti-cat IgE but not wheeze at age 5 in a low income urban NYC cohort" J Allergy Clin Immunol in press 2008

Perzanowski MS, Canfield SM, Chew GL, Mellins RB, Hoepner LA, Jacobson JS, Goldstein IF "Birth order, atopy, and symptoms of allergy and asthma among inner-city children attending Head Start in New York City." Clin Exp Allergy in press 2008

Perzanowski MS, Chew CG, Aalberse R, de Blay F "Allergic Asthma" Public Health Significance of Urban Pests Ed. Bonnefoy, Kampen, Sweeney World Health Organization Copenhagen/Denmark 7-52 2008

Perzanowski MS, Miller RL, Thorne PS, Barr RG, Divjan A, Sheares BJ, Garfinkel RS, Goldstein IF, Perera FP, Chew GL "Endotoxin inner-city homes and the association with atopy and wheeze in the first two years of life." J Allergy Clin Immunology in press 2006

Chew GL, Correa JC, Perzanowski MS "Mouse and cockroach allergens in the dust and air in Northeastern United States inner-city public high schools." Indoor Air 15 228-34 2005

Perzanowski MS, Ronmark E, Platts-Mills TA, Lundback B "The protective effect of having a cat or dog at home on developing asthma in pre-teen age children." Amer J Respir Crit Care Med 166 696-702 2002

Perzanowski MS, Ng'ang'a LW, Carter MC, Odhiambo J, Ngari W,Vaughan JW, Chapman MD, Kennedy MW, Platts-Mills TA "Atopy, asthma and antibodies to Ascaris among rural and urban children in Kenya: markers of allergy do not predict bronchial hyper-reactivity in a rural community." J Pediatr 140 582-588 2002

Perzanowski MS, Ronmark E, Nold B, Lundback B, Platts-Mills TA "Relevance of allergens from cats and dogs to asthma in the northernmost province of Sweden." J Allergy Clin Immunol 103 1018-24 1999

Perzanowski MS, Sporik R, Squillace SP, Gelber LE, Call R, Carter MC, Platts-Mills TA "Sensitization to Alternaria as a risk factor for asthma in school age children" J Allergy Clin Immunol 101 626-632. 1998

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